Under the supervision and presence of Prof. Dr. Edrees Muamad Tahir Harki, the Rector of the Erbil Polytechnic University, on Tuesday, the 17th of October, 2023, completed a training course arranged to improve the capacities and skills of the college alumni.
In the ceremony, where the Dean of the Erbil Technical Health and Medicine College, his deputy, and several lecturers were available, the university Rector delivered a speech and congratulated the Erbil Technical Health and Medicine College for conducting such courses for graduates. He shed light on the influence of existing relationships between university graduates and their departments and the importance of opening such training courses to improve their level and ability that help them to easily find jobs in the labor market in the future.
The course lasted for 10 days in which the topics related to skills and the latest developments in all fields were explained to the university graduates and focused on the topics that make it easier to get job opportunities.
At the end of the ceremony, certificates were awarded to the participants.
On Tuesday, the 17th of October, 2023, in the conference hall of the Erbil Polytechnic University, in the presence of Prof. Dr. Edrees Muhamad Tahir Harki, the university Rector, Asst. Prof. Mr. Umed Arshad Hawezi, the Dean of the Erbil Medical Technical Institute, a large number of teachers and students a health workshop was held under the title of (World Vision Week and Day, the Vision Protection is the Human Health Protection).
At the beginning, Prof. Dr. Edrees Muhamad Tahir Harki the Rector of the University, welcomed the teachers and students and said: We are pleased that the Erbil Medical Technical Institute has brought us together again today on the occasion of Vision Week. I appreciate their great efforts because it is not the first time, they have gathered us in this hall for the days related to human health and life. Vision Week is within the effective days in the world.
Ladies and gentlemen, the department of eye examination has always continued to present seminars and workshops which is commendable. Other departments of the institute have done such works. In fact, the Medical Technical Institute should pay more attention to these issues not only for students, teachers and university staff, but also to enter the community and interact with the community. Society constantly needs the knowledge that university teachers have to listen to and use in life, especially in general health, whether it is vision or medicine and birth I think these activities should continue, especially workshops and seminars. For example, we should go to a neighborhood around Erbil and give seminars to the people there on any topic I am very pleased with the activities carried out in the institute. I hope to expand it. We would like to thank the department of eye examination and the deanship of the institute for conducting this workshop.
Then Prof. Murad Amir Ahmad presented a special seminar on World Sight Day, then Dr. Sami Jalal Abdulsamad, Dr. Diyar Abdulqadir Ibrahim and Dr. Beriwan Abdulqadir Ali presented their special health seminars, in which the topics of the workshop were explained in detail to the participants.
Afterwards, the door of questions and discussions was opened for the participants to answer questions about the topics and they were answered by expert doctors.
Before the end of the workshop, the workshop presenters were awarded certificates of appreciation by the Rector.
Colorectal cancer (CRC) is the third most diagnosed tumor worldwide, with a very high mortality rate. The treatment strategies, such as surgery, chemotherapy, or radiotherapy, are not effective enough and show several limitations. Therefore, emerging strategies, such as nanomedicine offers a very powerful tools for cancer treatment. Recently, the combination of nanoparticle antitumor effect with a triggering external stimulation was formulated to boost up the cytotoxic activity. In the present study, the synergistic action of Zinc oxide nanoparticles and Diode laser was assessed in the treatment of Colorectal cancer cell line (Caco2) in vitro.
Different concentrations of ZnO2-NP (0.5, 1, 5, 10, 20, 40, 75, 100, 200, 1000) µg/ml were used for cytotoxic action. In addition, targeted laser power of (5 j/cm2). The combination of ZnO2-NP and Diode laser for the cell was evaded properly. IC50 for CaCo2 was 20 µg/ml. The cytotoxic action was measured via MTT Assay for (24,48 and 72 hrs), while Flowcytometery (Propidium Iodide, Annexin VAssay) was applied for detection of apoptosis, while, analysis of cell cycle arrest was measured by flowcytometry. Moreover, the relative expression level of (P53, Bax, and Bcl2) was measured using quantitative real-time PCR (qPCR). Reactive Oxygen Species-level was determined by dichlorofluorescein diacetate (DCFDA) Assay method.
The percentage of cells that decreased in the G2 phase of the cell cycle relative to the S and G1 phases was significantly different when laser and zinc nanoparticles were combined (p-value<0.05). Significantly substantial variation in the use of a diode laser and zinc nanoparticles to stop the spread of cancer by boosting the expression of the p53 gene (p-value<0000). Bax, a key pro-apoptotic component of the B-cell lymphoma 2, is an essential gateway to mitochondrial dysfunction and was significantly expressed in the study (p-value<0.05) after cell treatment. Utilizing the laser and zinc nanoparticles together did not reveal any substantial differences in the Bcl2 gene (p-value>0.05). Results of different techniques used in the study supported that combination therapy of ZnO2 and Diode laser is cytotoxic to Colorectal cancer in vitro and there is a possibility of developing an effective therapeutic agent against Colorectal cancer. The finding of cytotoxicity is a significant difference in combination therapy on the number of cells experiencing early apoptosis compared to live, late apoptosis, and necrosis (p-value<0.05). Highly noticed modifications and significant differences have been reported when the proportion of cell lines in DCFH- compared to DCFH+ has been reduced using laser and zinc nanoparticles alone or together (p-value<0.05), the percent of cells in the control remains at high rates and decreased in all treated cases with different ratios.
This study demonstrated that the combination of zinc oxide nanoparticles and diode laser therapy on colorectal cancer cells (Caco-2) in vitro, showed a synergistic anticancer impact.
