Category Archives: Master Thesis

HLA-B*0702 Class-I Allele, Anti-FSH, Anti-LH, and Vitamin D3: Potential Links with Polycystic Ovary Syndrome in Women of Erbil City, Iraq

  • Rand Maurice Aziz
  • [email protected]
  • 0751 534 3069
  • (Rand Maurice Aziz) M.Sc Thesis Final
  • Polycystic Ovary Syndrome (PCOS) is regarded as a global health problem since its causes and diagnosis have confused many researchers to this day. This study aims to investigate the impact of four important parameters on PCOS in women of Erbil city, including Human Leukocyte Antigen (HLA) represented by the HLA-B*0702 allele, Anti-Follicle Stimulating Hormone (anti-FSH) antibodies, Anti-Luteinizing Hormone (anti-LH) antibodies, and vitamin D3. It is regarded as novel in this field. For this purpose, one hundred blood samples, including EDTA for molecular characterization and serum samples for immunological analysis were collected from (60 PCOS patients and 40 healthy controls) who attended the Maternity Teaching Hospital and some private clinics and hospitals in Erbil City between October 2021 and January 2022. After DNA extraction, all of the extracted DNA samples were genotyped using a PCR-based approach with specific sequence primers. Anti-FSH and anti-LH antibodies serum levels were assessed by Enzyme-Linked Immunosorbent Assays (ELISA), whereas vitamin D3 assessment was done using an Electrochemiluminescence (ECL) technology on a Cobas e411 immunoassay analyzer.

    The outcomes of the study, with an odds ratio (OR) of 2.167 at a 95% confidence interval (CI) of 0.8167 to 6.330, signifies a higher risk and suggesting that the syndrome is more common with the HLA-B*0702 allele which is harmful in this case. The serum levels of anti-FSH and anti-LH antibodies in primary infertile PCOS patients were significantly higher than in the control group and secondary infertile PCOS patients. A significant positive linear relationship was also discovered between these antibodies (P-value < 0.0001). Furthermore, anti-FSH antibodies showed a significant positive correlation with FSH, just as anti-LH antibodies did with LH (P-value < 0.01). However, both antibodies demonstrated non-significant positive correlations with the LH/FSH ratio and non-significant negative relationships with vitamin D3 (P-value ≥ 0.05). Hypovitaminosis D3 was observed in most PCOS patients and healthy controls with a significant difference (P-value < 0.01). According to the findings, the HLA-B*0702 allele is linked to PCOS susceptibility and could be employed as an immunogenetic marker. The results also supported the idea that antibodies against follicle-stimulating hormone and luteinizing hormone are naturally found antibodies in PCOS patients rather than signs of autoimmune disease. Women with PCOS are additionally more inclined to develop vitamin D3 deficiency.

  • Erbil Technical Health College
  • Medical Laboratory Technology
  • Immunology

association of PPARG and FTO polymorphism with type 2 diabetes in Kurdistan region

  • sally khalil baqer
  • [email protected]
  • 0772 264 7692
  • sally final thesis - Copy
  • Type 2 Diabetes (T2D) is the most common form of diabetes; it develops when pancreatic cells produce an excess amount of insulin, resulting in insulin resistance by peripheral cells. T2D is an illness that caused by interaction between genetics and environmental factors. Genetic factors are involved in the development of T2D and several genetic variants increase the risk to have T2D. The single nucleotide polymorphisms (SNPs) rs1801282 in the Peroxisome Proliferator-Activated Receptors gamma) PPARG (gene and rs9939609 in the Fat mass and obesity associated protein (FTO (gene were discovered to be related to raising the risk of T2D in different populations. This research aimed to discover if rs1801282 in the PPARG gene and rs9939609 in the FTO gene are responsible for increasing the risk of T2D in Kurdistan region. In the current study DNA from 200 unrelated individuals (100 T2D, and 100 non-diabetic control) were genotyped using Allele-specific PCR for both SNPs. The accuracy of the PCR methods used were validated by the Sanger sequencing method.

    The association analysis for the rs1801282 (adjusted by sex, age, and BMI) showed significant differences between the cases and the control groups for rs1801282, individuals with genotypes (GG, and GC) had a higher risk of the disease (p-value = 0.0045, OR = 3.96, 95%CI: 1.31-11.94) than genotype (CC). the contrary, there was no significant differences (p value= 0.39) between the case and control groups for the rs9939609 variant in the FTO gene.

    The findings in this research suggested that the variant rs1801282 in the PPARG gene was a genetic susceptible SNP in T2D in the Kurdish population, while SNP rs9939609 in the FTO gene was not associated with T2D. Further investigations with larger number samples are required to validate these findings.

  • Erbil Technical Health College
  • medical laboratory technique
  • medical laboratory Technique

دور تكنولوجيا الاتصال الحديثة في تفعيل أداء العلاقات العامة (القنوات الفضائية والمحلية في إقليم كوردستان أنموذجا)

  • دلشین دیاب عبداللة
  • [email protected]
  • 0750 125 2079
  • دور تكنولوجيا الاتصال الحديثة في تفعيل أداء العلاقات العامة
  • يهتم هذا البحث الذي يحمل عنوان (دور تكنولوجيا الاتصال الحديثة في تفعيل أداء العلاقات العامة-القنوات الفضائية والمحلية في إقليم كوردستان أنموذجا) بالعلاقات العامة ودور تكنولوجيا الاتصال في تفعيل أدائها، إذ برزت أهمية البحث في إظهار الجوانب الإيجابية لتكنولوجيا الاتصال الحديثة، والاستفادة منها داخل المؤسسات الإعلامية وأقسام العلاقات العامة وأهمية العلاقات العامة داخل القنوات الفضائية والمحلية ودورها في التواصل مع جمهور المؤسسة ومع باقي المؤسسات عبر استخدام تكنولوجيا الاتصال الحديثة.

    منهجياً يقع البحث ضمن البحوث (الوصفية)، التي تعتمد على منهج (المسح)، فيما تمثل مجتمع البحث بالقنوات الفضائية والمحلية في إقليم كوردستان، وحدد العاملين في أقسام العلاقات العامة داخل هذه القنوات كعينة للبحث، وتم استخدام استمارة الاستبيان كأداة رئيسية للبحث، إذ بلغ عدد أسئلة استمارة الاستبيان الذي تم تصميمه عبر تطبيق (google forms ) 38 سؤال وفقرة، وتم استخدام البرنامج الاحصائي (SPSS) لتحليل البيانات واستخراج النتائج المطلوبة، فيما تمثل الهدف الرئيسي في إظهار الدور الذي تلعبه تكنولوجيا الاتصال الحديثة لتفعيل أداء العلاقات العامة بالقنوات الإعلامية في الإقليم.

    وتمثلت أهم استنتاجات البحث في: 1. أظهرت النتائج الميدانية أن اقسام العلاقات العامة ضمن القنوات الاعلامية تفتقر الى وجود قسم مختص بهم فيما يتعلق بتكنولوجيا الاتصال الحديثة.

    1. استطاعت العلاقات العامة باستخدام تكنولوجيا الاتصال الحديثة أن تقوي علاقاتها المالية مع محيطها بالإضافة الى تمتين علاقاتها مع بقية الوسائل الاتصالية.
    2. أظهرت النتائج الميدانية أن العلاقات العامة في المؤسسات الإعلامية بإقليم كوردستان تفتقر لوجود مختصين في مجال تكنولوجيا الاتصال الحديثة.

    الكلمات المفتاحية: دور، تكنولوجيا الاتصال الحديثة، تفعيل، أداء، العلاقات العامة، القنوات الفضائية والمحلية، إقليم كوردستان.

  • Erbil Technical Administrative College
  • میدیا
  • میدیا

An Experimental and Numerical Investigation of Mechanical Properties of Unidirectional Fiber Epoxy Composite

  • Naznaz Jalal Awla
  • [email protected]
  • 0780 541 3331
  • WITHOUT HIGHLITEDd
  • ABSTRACT

    The composite of carbon fiber and fiber glass received enormous attention from research communities in the field of epoxy layers of composite. In this study, the mechanical properties of the epoxy and Unidirectional Carbon with fiberglass composite in different volumes of fraction in fibers were experimentally and computationally investigated. American Society for Testing and Materials (ASTM) used in this study for preparing the composite samples. Tensile, impact and flexural tests were conducted to investigate the mechanical properties of the new produced of epoxy Unidirectional Carbon and Epoxy Fiberglass composites. The outcome of the experimental demonstrated that the strength of the produced samples increased with the increase in the number of Unidirectional Carbon layers and the maximum rate was % 15 of lower density of epoxy resin and other was % 5.5. In addition, four different composites were utilized: (1) woven carbon composite with glass fiber (2) woven carbon with epoxy resin composite. (3) Fiber glass with epoxy resin composite (4) Epoxy resin only. While the process of comparing the result in computational way by using Finite Element Method and using ANSYS 2022 R1 Work bench noted that the computational samples are stronger than experimental tested samples, because of the inter face reactions between and bonding in actual situation don’t takes place completely for the purpose of using hand lay-up method for conducting samples in experimental. When comparing the strengthen of two reinforcement fibers the results explained that woven carbon composite has higher mechanical resistance. While in tensile and impact tests the strength of samples increased with adding layers of wight percentage (1.5% UDC by 3% fiber glass), (3% UDC by 1.5% fiber glass) and (3% UDC by 3% fiber glass) of mixture of and epoxy resin. Meanwhile, in flexural test the most strengthen sample was with the one that contains highest layer of percentage which was 15% of fiber glass for the first group of Master Protect 180, while in the second group Master Brace ADH 1406 the most strengthen sample was with the one which contains unidirectional carbon fiber layers.

  • Erbil Technical Engineering College
  • Mechanical and Energy Engineering
  • Mechanical Applied